To get espresso grind in the range that produces a decent pull in the 30 seconds, my current Vario setup is Macro-> all the way to the top, Micro-> 4 from the top. For AP and my newly acquired Kone/Chemex, I then only move the Macro to the bottom.
I know I could adjust the grinder to give me more "selection" at the espresso range of the grinder, but it seems that I lose coarseness at the drip range of the grinder. IMO, the range is limited if the only adjustment you are making are the macro/micro sliders. Adjusting the hex screw for coarser grinds, and lose espresso fineness, or adjust the hex screw for espresso fineness and lose the coarseness of the grind. The limiting factors for each person then becomes your method of brewing (what type espresso machine and drip/pour-over/frenchpress...).